Page 94 - ISMCON souvenir 2021

ISMSCON - 2021

OS72: Effect of Ivermectin Prophylaxis in Prevention of COVID
19 – Meta-Analysis and Systematic Review

Manisha Kujur , Kumari Asha Kiran ,Alka Rashmi Nag , Anit Kujur , Amit Kumar , Vidyasagar 6
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Introduction
Ivermectin was popular drug on trial for preventive and therapeutic role in COVID-19 .So our Study was
to assess the effect of Ivermectin Prophylaxis in Prevention of COVID 19 .
Methods
The online databases of PubMed (Central), Medline, and Google scholar for randomized controlled trials,
Non-randomized trial and prospective cohort study were searched up to March 2021. Nine studies were
included for analysis, out of which four were RCTs, Two Non-RCTs and three cohortstudies.
Results
Four randomized trial evaluated prophylactic drug Ivermectin,two combination of topical nasal
carrageenan and oral Ivermectin two study used in combination of personal protective equipment (PPE)
one with IVER and one with IVER/IOTACRC.In the pooled analysis we observed non-significant less
COVID-19 positivity rate in the prophylaxis group as compared to non-prophylaxis group (RR= 0.27 and
CI= 0.05, 1.41) with significant heterogeneity (I = 97.1%, p value <0.001)The pooled analysis involving
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the non-RCTs studies also did not observe significant reduction in the COVID-19 positivity rate in the
prophylaxis group as compared to non- prophylaxis group (RR= 0.01 and CI= 0.00, 7.97) with significant
heterogeneity between the studies (pvalue<0.001).
Conclusion

Ivermectin is not the ‘magical silver weapon’ against COVID-19 .
Keywords: Ivermectin, COVID-19, Meta analysis, Systematic Review

92 CONFERENCE SOUVENIR